Pharmacological and Toxicological Studies on a New Hypolipidemic Agent, NIP-200

Mechanisms of the hypolipidemic effect of NIP-200 in rats.

We studied the mechanisms of hypolipidemic effects of NIP-200 (3,5-dimethyl-4,6-diphenyltetrahydro-2H-1,3,5-thiadiazine- 2-thione), a potent hypolipidemic compound, in cholesterol biosynthesis in the liver, cholesterol absorption in small intestine, and cholesterol catabolism and excretion in rats. NIP-200 did not reduce cholesterol biosynthesis and had no effects on cholesterol absorption in t...

Some Pharmacological and Toxicological Studies on Some Egyptian Plants

In this work phytochemical, pharmacological and toxicological studies were carried out on Eruca saliva,Petroselinum crispum and Anethum graveolens alcoholic extract. LDso of these extracts can not be detected, when given orally in mice. These alcoholic extracts inhibit rabbit's intestinal motility . Eruca sativa extract stimulates the uterine motility of all stages of sex cycle, while Petroseli...

Clinical pharmacological studies of Kö 1173--a new antiarrhythmic agent.

A Review on Phytochemical, Pharmacological and toxicological studies on Neolamarckia cadamba

Neolamarckia cadamba is one of such ayurvedic remedy that has been mentioned in many Indian medicinal literatures. This article discusses about the medicinal values of Neolamarckia cadamba. In this communication, we reviewed the morphology, microscopy, phytochemistry of Neolamarckia cadamba and its application in the treatment of various ailments like diabetes mellitus, diarrhoea, fever, inflam...

Micronized fenofibrate: a new fibric acid hypolipidemic agent.

OBJECTIVE To review the efficacy and safety of fenofibrate in the management of hyperlipidemias. DATA SOURCES A MEDLINE search (1974-October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation. Studies evaluating fenofibrate (peer-reviewed publications, package insert data) we...